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Precision in dosing affects three critical outcomes

EAR, early asthmatic reaction

Recent data from the ATTAIN-MAINTAIN trial showed that patients transitioning to orforglipron after injectable GLP-1 therapy maintained their weight loss with minimal regain (approximately 0.9 kg after semaglutide transition), suggesting that oral maintenance strategies could minimize the lean mass depletion seen with prolonged high-dose injectable therapy

Mild local reactions may not require discontinuation, but medical evaluation is necessary to determine whether subsequent doses are safe

TABLE 1 Pharmacokinetics of exendin-4 in portal and peripheral blood after administration via the intestine, or by intravelous injection