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demonstrated that metformin inhibited PDGF-induced phosphorylation of AKT, FoxO1 and mTOR/p70S6K (two downstream targets of the phosphatidylinositol 3-kinase/AKT pathway), resulting in the inhibition of HSC proliferation and migration, the reduction of extracellular matrix secretion consisting of -SMA, type I collagen and fibronectin, which leads to inhibition of fibrosis (64, 65)

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This product must remain refrigerated to maintain efficacy

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