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GLP-1 RAs Several clinical trials have compared the clinical efficacy and safety profiles of GLP-1 RA and DPP-4 inhibitors in patients with T2DM (Table 1)

Given the increasing availability of CV safety outcomes data for glucose-lowering medications, it has become apparent that certain agents within the GLP-1RA and SGLT-2 inhibitor classes reduce the risk of CV events in those with high-risk CV or CKD [16,17,18,19,20,21]

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Key Takeaway: Early Detection Through Body Composition Body composition changes appear before weight gain

S., & Kolonin, M

Key findings include: TRIUMPH-4 Trial : Participants with obesity and knee osteoarthritis experienced substantial weight loss and pain reduction