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By integrating molecular, pharmacological, electrophysiological and dietary manipulations, our study aims to provide deeper insight into how AgRP neurons contribute to GLP-1R agonist-mediated weight loss and whether their role is modulated by diet-induced shifts in feeding circuitry
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One documented case involved a 44-year-old woman who developed elevated liver enzymes after starting semaglutide, with levels normalizing after discontinuation and worsening upon rechallenge
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