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Loss of BBB integrity in AD may result in the entry of neurotoxic and pro-inflammatory molecules as well as a reduced clearance of -amyloid (A) that may invoke local inflammatory responses, and in turn initiate multiple pathways of neurodegeneration (Sweeney et al., 2018
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
A 24-week phase 2 trial of tesofensine results in a mean weight loss of 4.5%, 9.2% and 10.6% at doses of 0.25 mg, 0.5 mg, and 1.0 mg, respectively, all compared to 2.0% for the placebo group (140)
In this sense, the two approaches are not necessarily competing
In the mixed urine samples collected from 0 to 8 h, the content of [ 3 H]proline (M1), the main metabolite, was higher, accounting for 13.9% (female) and 11.7% (male) of the total radioactivity
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