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Retatrutide targets GLP-1, GIP, and glucagon receptors for comprehensive metabolic action Phase 2 trials showed up to 24% body weight loss over 48 weeks in participants The medication is administered as a once-weekly injection, similar to existing treatments Eli Lilly is developing Retatrutide, with Phase 3 trials currently underway UK availability is not expected until at least 2026-2027 following regulatory approval Weight Loss Treatment Comparison Calculator Estimate potential weight loss based on current clinical trial data for different medications Based on average clinical trial results
Lilly plans to submit a Biologics License Application during the first quarter of 2027
Prospective, controlled studies are needed to clarify whether GLP-1RAs have a direct therapeutic role in HS or act primarily through effects on weight and metabolic inflammation
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