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More recently, Choi and colleagues evaluated the cost-effectiveness of SGLT2is and GLP-1RAs, taken individually, as first-line therapies for American patients with T2DM, compared with metformin as first-line therapy

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They also note that weight regain has been reported with other weight loss methods, such as gastric bypass and vertical banded gastroplasty

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The company said these are unapproved knockoffs, often made with illicit foreign active pharmaceutical ingredients (API), and have not been proven safe or effective