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A narrative review was conducted based on a literature search for randomised controlled trials, cohort studies, case reports, and systematic reviews reporting outcomes of GLP-1 RAs therapies in SIH and SID
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Overall, when prescribed correctly and monitored closely, Sermorelin therapy appears to offer a safe option for individuals seeking to boost growth hormone levels to address deficiencies or optimize health outcomes
Some clinical experts and recent Phase 3 reporting have also noted that weight loss in some participants has been substantial enough to raise questions about how much weight loss may be too much, particularly when these medications are used outside tightly controlled medical settings and without provider supervision
"Behavior is always important but you have to let the pharmacology work." While there is no standard protocol to follow, Ashton said a doctor may try to get a patient to their target, healthy goal weight and then follow the "basic principle of pharmacology" in decreasing the patient to the lowest dose of the medication possible
Children, unless recommended by their doctor
